1. 个人简介:
韩磊,生于山东青岛,中共党员,工学博士,教授,博导,山东省优秀研究生导师,泰山学者青年专家,山东省优青项目获得者。现任教于77779193永利官网,永利集团官网,担任77779193永利官网生物纳米与分子识别研究室负责人、山东省青创引育计划团队负责人。近三年连续入选全球前2%顶尖科学家榜单(连续两年进入终身科学影响力排行榜)。2010年于中国科学院天津工业生物技术研究所获硕士学位(化学工程);2016年于中国科学院青岛生物能源与过程研究所获博士学位(化学工程);2016年以高层次人才引进到77779193永利官网,永利集团官网;2019年-2020年在香港科技大学唐本忠院士团队学习交流。
2. 邮箱:hanlei@qau.edu.cn
3. 个人主页:
/channel/hanlei
https://orcid.org/0000-0003-1955-0718
https://www.scopus.com/authid/detail.uri?authorId=56416900000
https://webofscience.clarivate.cn/wos/author/record/L-2414-2016?state=%7B%7D
4. 团队简介:
生物纳米与分子识别研究室(Lab of Bio-Nano & Molecular Recognition)拥有一支年轻而富有活力、多学科交叉、专业结构匹配、年龄结构合理、高效精干的创新型科研学术团队。教师队伍包括教授4人、副教授1人、实验师1人,均为博士学历,拥有海外背景5人,涵盖应用化学、材料学、分析化学、有机化学、农业工程、微生物学、农药学等多个学科专业。团队围绕社会需求,面向国际科技前沿问题,致力于生物纳米与分子识别方面的研究,形成了具有鲜明特色和优势的研究方向:生物纳米材料(纳米酶、生物无机杂化纳米材料)、仿生矿化、噬菌体展示文库的构建和配体筛选、微生物细胞表面展示、有机荧光探针的合成及上述识别元件在农业生产、农残快检、食品分析、医疗、海洋环境、便携式传感器等领域的应用。
团队主页:/channel/ksll
5. 研究方向:
(1) 生物纳米材料:纳米酶、仿生纳米材料、生物矿化材料的设计与合成;
(2) 微生物表面展示:细菌表面展示、噬菌体展示文库、特异性生物探针淘选;
(3) 有机合成:有机荧光材料及金属有机配合物的设计、合成与应用;
(4) 传感分析:电化学传感、光电化学传感、电致化学发光、化学发光、荧光分析、比色分析及其商业化检测装置的开发;
(5) 智慧农业应用研究:上述三类识别元件(生物纳米材料、有机荧光探针、微生物表面展示系统)在智慧农业、畜牧业、海洋牧业、食品安全等大农业领域的应用研究(包括智能传感、荧光成像、杀菌防病、改善作物生长等);
6. 科研经历:
近年来,先后主持包括国家自然科学基金面上项目、国家自然科学基金青年项目在内的科研项目8项。目前在研项目包括国家自然科学基金面上项目、山东省自然科学基金优青项目等4项,在研经费共计400万。
在Advanced Functional Materials、Chemical Engineering Journal、Journal of Hazardous Materials、Analytical Chemistry、Biosensors and Bioelectronics、Aggregate、JACS Au等权威期刊上以第一/通讯作者发表SCI论文60余篇,累计IF>500,总被引频次3000余次,其中一区期刊论文21篇,影响因子大于10的论文12篇,单篇被引百次以上的论文9篇,积累了较丰富的研究经验。以第一发明人申请发明专利30余件,其中已授权中国发明专利17件,海外授权发明专利4件,建立了一定的知识产权保护体系。
2020年获山东省高等学校科学技术奖二等奖(首位),2021年获山东化学化工学会科学技术奖二等奖(首位)。
曾在International Conference on Aggregate Science、微米纳米技术与医疗健康创新大会等多个国际国内会议上做邀请或口头学术报告。
现任Frontiers in Chemistry审稿编辑、Exploration青年编委,长期担任Advanced Materials、ACS Nano、Analytical Chemistry、Biosensors and Bioelectronics、Journal of Hazardous Materials等40余个国际SCI期刊的审稿专家。
7. 主讲课程:
研究生课程:《生物化学工程》、《化学与生物传感》、《创新思维训练》
本科生课程:《化学与生物传感》、《分析化学》(生物类)、《食品化学与分析》、《基础化学实验》等9门课程
8. 代表性SCI论文:
[1] Yanfang Zhao, Haiying Chen, Chao Chang, Lubin Xu, Lei Han*. Clusterization-triggered emission artiffcial enzyme (CTEzyme) with specific activity inhibition boosting ratiometric fluorescence detection of pesticide. Sensors and Actuators: B. Chemical, 2025, 432, 137491. (一区,影响因子IF=8.0)
[2] Haiying Chen, Baojian Huang, Lei Han*. Enhanced performance of bacterial laccase via microbial surface display and biomineralization for portable detection of phenolic pollutants. Journal of Hazardous Materials, 2025, 137957. (一区,影响因子IF=12.2)
[3] Yihui Shen, Baojian Huang, Hang Yao, Guogang Shan, Yingying Shao, Xin Zhou, Lei Han*, Chengcheng Zhou*. In-vivo spectral recomposition of sunlight with glycosylated aggregation-induced emission antennas for boosting photosynthesis. Journal of Colloid and Interface Science. 2025, 688, 784-795. (一区,影响因子 IF=9.4)
[4] Xinyan Guo, Yucui Zhang, Baojian Huang, Lei Han*. Organophosphorus Hydrolase-like Nanozyme with an Activity-Quenched Aggregation-Induced Emission Effect: A Self-Reporting and Specific Assay of Nerve Agents. Analytical Chemistry. 2024. 96(42). 16695-16705. (一区,Nature指数期刊,影响因子IF=6.7,封面文章)
[5] Haiying Chen, Xin Zhang, Weimin Gao, Baojian Huang, Lei Han*. Reversible uncompetitive inhibition of metal–organic framework nanozymes: specific colorimetric assay of methidathion without enzymes. Chemical Communications. 2024. 60(92). 13522-13525. (Nature指数期刊,IF=4.3,封面文章)
[6] Yanfang Zhao, Yucui Zhang, Xin Liang, Da-Peng Yang, Lei Han*. The influence of substrates addition order on colorimetric assay based on MnO2 nanocubes: A novel turn-off H2O2 assay strategy in water-soak foods. Food Chemistry. 2023. 419. 136059. (一区,IF=8.5)
[7] Yanfang Zhao, Jing Yang, Yuqing Wu, Baojian Huang, Lubin Xu, Jianming Yang, Bo Liang, Lei Han*. Construction of bacterial laccase displayed on the microbial surface for ultrasensitive biosensing of phenolic pollutants with nanohybrids-enhanced performance. Journal of Hazardous materials. 2023. 452. 131265. (一区,IF=12.2)
[8] Xiuzhong Wang, Zhen Wang, Fengying Dong, Dongxu Yang, Li Yin, Lei Han*. Exploration of Water-Soluble Natural AIEgens Boosting Label-Free Turn-on Fluorescent Sensing in a DNA Hydrogel. Analytical Chemistry. 2023. 95(37). 13864-13871. (一区,Nature指数期刊,IF=6.7,封面文章)
[9] Lei Han*, Yucui Zhang, Baojian Huang, Xuhui Bian, Ben Zhong Tang. Aggregation-induced emission artificial enzyme (AIEzyme) with DNase-like activity: Imaging and matrix cleavage for combating bacterial biofilm. Aggregate. 2023. 4(5). e360. (国内SCI,一区, 影响因子IF=18.0)
[10] Yanfang Zhao#; Xin Liang#; Daoyuan Chen; Xuhui Bian; Wanjian Liu; Lei Han*; Denatured proteins show new vitality: Green synthesis of germanium oxide hollow microspheres with versatile functions by denaturing proteins around bubbles, Aggregate 2023. 4(1). e204. (国内SCI,一区, 影响因子IF=18.0)
[11] Zhen Wang#; Yucui Zhang#; Xiuzhong Wang*; Lei Han*; Flow-homogeneous electrochemical sensing system based on 2D metal-organic framework nanozyme for successive microRNA assay, Biosensors and Bioelectronics, 2022, 206: 114120. (一区, 影响因子IF=12.545)
[12] Xin Liang; Xiuzhong Wang; Yucui Zhang; Baojian Huang; Lei Han*; Selective inhibition toward dual enzyme-like activities of iridium nanozymes for a specific colorimetric assay of malathion without enzymes, Journal of Agricultural and Food Chemistry, 2022, 70(12): 3898-3906. (一区,IF=5.895,封面文章)
[13] Xuhui Bian; Daoyuan Chen; Lei Han*; Taking full advantage of the structure and multi-activities of mineralized microbial surface-displayed enzymes: Portable three-in-one organophosphate pesticides assay device, Chemical Engineering Journal, 2022, 429: 132317. (一区,IF=16.744)
[14] Chenchen Liu, Xuhui Bian, Ryan T. K. Kwok, Jacky W. Y. Lam, Lei Han*, Ben Zhong Tang*. Biological Synthesis and Process Monitoring of an Aggregation-Induced Emission Luminogen-Based Fluorescent Polymer. JACS Au. 2022. 2(9). 2162-2168. (IF=8.5)
[15] Xiaolin Liu#; Xin Liang#; Yubing Hu#; Lei Han*; Qing Qu; Dongming Liu; Jing Guo; Zebing Zeng; Haotian Bai; Ryan T. K. Kwok; Anjun Qin; Jacky W. Y. Lam*; and Ben Zhong Tang*; Catalyst-free spontaneous polymerization with 100% atom economy: Facile synthesis of photoresponsive polysulfonates with multifunctionalities, JACS Au, 2021, 1, 3: 344–353. (IF=8.5)
[16] Bo Liang; Lei Han*; Displaying of acetylcholinesterase mutants on surface of yeast for ultra-trace fluorescence detection of organophosphate pesticides with gold nanoclusters, Biosensors and Bioelectronics, 2020, 148: 111825. (一区,IF=12.545)
[17] Xin Liang; Lei Han*; White peroxidase-mimicking nanozymes: White peroxidase-mimicking nanozymes: Colorimetric pesticide assay without interferences of O2 and color, Advanced Functional Materials, 2020, 30, 28: 2070184. (一区,IF=19.924)